Stages in spheronisation: Evolution of pellet size and shape during spheronisation of microcrystalline cellulose-based paste extrudates
•Tests with coloured pastes show that fines do not attach preferentially at pellet waist.
•New ‘dumb-bellity’ measure to quantify the formation of dumb-bells
•Spheronisation time increases with mass of charge until overmassing occurs.
•Tests with calcium carbonate as model API exhibit the same behaviour.
http://www.sciencedirect.com/science/article/pii/S003259101400864X