Novel oral formulation approach for poorly water-soluble drug using lipocalin-type prostaglandin D synthase.
Eur J Pharm Sci. 2015 Apr 20. pii: S0928-0987(15)00155-4. doi: 10.1016/j.ejps.2015.04.012.
Lipocalin-type prostaglandin D synthase (L-PGDS), a member of the lipocalin superfamily, possesses the function of forming complexes together with various small lipophilic molecules. In this study, we chose telmisartan as a model drug due to its pH dependent poor water solubility, and developed and characterized a novel solubilized formulation of telmisartan using a complex formulation with L-PGDS…