Investigation of Drug–Excipient Interactions in Lapatinib Amorphous Solid Dispersions Using Solid-State NMR Spectroscopy

02. March 2015

Mol. Pharmaceutics, 2015, 12 (3), pp 857–866

DOI: 10.1021/mp500692a

Publication Date (Web): January 13, 2015

This study investigated the presence of specific drug–excipient interactions in amorphous solid dispersions of lapatinib (LB) and four commonly used pharmaceutical polymers, including Soluplus, polyvinylpyrrolidone vinyl acetate (PVPVA), hydroxypropylmethylcellulose acetate succinate (HPMCAS), and hydroxypropylmethylcellulose phthalate (HPMCP)…

http://pubs.acs.org/doi/abs/10.1021/mp500692a?mi=2gvdg1k&af=R&field1=AllField&targetTab=std&text1=excipient&target=default&sortBy=Earliest