Modulation of the wettability of excipients by surfactant and its impacts on the disintegration and release of tablets
Objective: To investigate the modulation of the wettability of excipients by types of surfactants and its impacts on the disintegration of tablets and drug release.
Materials and methods: The critical micelle concentration (CMC) of surfactants including sodium dodecyl sulfate (SDS), sodium dodecyl benzene sulfonate (SDBS), dodecyl trimethyl ammonium bromide (DTAB), cetyltrimethyl ammonium bromide (CTAB) and polysorbate (Tween-20 and Tween-80) was obtained using the platinum ring method. Contact angles of surfactant solutions on the excipient compacts and double-distilled water on the mixture of surfactant and the other excipient (magnesium stearate (MgSt) or sodium alginate (SA)) were measured by the sessile drop technique. Besides, surface free energy of excipients was calculated by the Owens method. Finally, the disintegration of tablets and in vitro dissolution testing were performed according to the method described in USP.