A new formulation has been developed successfully, which includes production of highly-porous mannitol particles with high surface areas through the spray drying of mannitol solutions containing ethanol-soluble sugar or food-grade acids as templating agents. The resultant porous particles after ethanol washing have been transferred to ethanol solutions containing the drug component. The results of this study showed that deposition of acetaminophen in the pore-space of highly-porous mannitol resulted in better blending uniformity of drug dosage, as well as a fast drug release rate due to nano-confinement of drugs into porous excipients. 

Keywords:  Adsorption; Templating process; High-porosity mannitol; Spray drying; Acetaminophen; excipient

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